Regulation of cholesterol metabolism was investigated in eight hypercholesterolemic and Slide-In Range five normal individuals by combined intravenous pulse-labeling with radioactive cholesterol and fecal steroids balance techniques.Mean serum cholesterol concentrations ranged from 168 to 717 mg/dl.Experiments were scheduled in the following sequen
Enhanced detection and study of murine norovirus-1 using a more efficient microglial cell line
Abstract Background Human Noroviruses are the predominant cause of non-bacterial gastroenteritis worldwide.To facilitate prevention and control, a norovirus isolated from mice can provide a model to understand human noroviruses.To establish optimal Slide-In Range viral infectivity conditions for murine noroviruses, several cell lines of hematopoiet
Integration of therapeutic cargo into the human genome with programmable type V-K CAST
Abstract CRISPR-associated (Cas) transposases (CAST) are RNA-guided systems capable of programmable integration of large segments of DNA without creating double-strand breaks.Engineered Cascade CAST function in human cells but are challenging to deploy due to the Handling Fee complexity of the targeting components.Unlike Cascade, which require thre
Xanthogranulomatous Appendicitis: A Rare Case Report
Xanthogranulomatous inflammation is a form of chronic inflammation where the exact eitiology is not known.It is commonly reported in organs like kidney and gall bladder Very few cases of xanthogranulomatous inflammation of appendix have been Collars reported in the literature.We report a case of 30 year female presenting with pain abdomen and fever